Single nucleotide variants in the SCN1A gene and their relation to the development of type 3 familial hemiplegic migraine

IntroductionMigraine is a complex brain disorder that influenced by different pathophysiological aspects such as inflammation, structural changes, and dysfunctions in multisensory processing. Recent studies have showed possible mutations genes interfere with the excitability of ion channels linked to nociception are one key mechanisms for development migraine. In this sense, it known familial hemiplegic migraine type 3 (FHM3) undergoes specific missense mutational influences on SCN1A gene encodes α1 subunit NAV1.1, voltage-gated sodium channel present demonstrates deregulation excitatory- inhibitory balance these circuits may come characterize pathogenic mechanism FHM3. ObjectivesInvestigate relation single nucleotide variants (SNVs) encoder a1 NAV1.1 MethodsNarrative review performed active search digital databases Virtual Health Library (BVS), PubMed, SciElo Google Scholar. DevelopmentMigraine pathophysiology involves distribution ions between intracellular extracellular compartments, which shows role disease. regard, there an activation trigeminal vascular meningeal system NaV1.1 channels, expressed Aδ fibers. Therefore, believed act migraine, mainly meninges, they densely innervated nerve endings. (To see complete abstract, please, check out PDF).